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Epicharmus of Kos (6th-5th century BC), comic playwright
- Hippocrates (5th century BC), “father of medicine”.
- Philitas of Cos (4th century BC), poet and scholar.
- Michael Kefalianos, professional bodybuilder.
- Marika Papagika, early 20th century singer.
- Kostas Skandalidis, former Interior Minister of Greece and close associate of Prime Minister Andreas Papandreou.
- Al Campanis, Major League Baseball player and executive.
- Stergos Marinos, international footballer currently playing for Panathinaikos.
Kos, Greece 